Aims

• To introduce an example of computational protein design.

Objectives

After this lecture you will:

• be aware of the computational approach to the inverse folding problem used in designing Top7.

Supplementary Material

The computational approach used to design Top7 is described in:

Kuhlman, B., Dantas, G., Ireton, G.C., Varani, G., Stoddard, B.L. and Baker, D. (2003) Design of a novel globular protein fold with atomic-level accuracy. Science, 302, 1364-1368 (PubMed)