Graham Kemp > Teaching > Bioinformatics III


Lecture GK-3

Comparative modelling


Aims

Objectives

After this lecture you will:

Supplementary Material

The lecture handout, featuring some of the lecture slides, is available on-line. (PDF)

Rob Russell has written A Guide to Structure Prediction that includes practical advice and links to useful software.

Several of the figures shown in the lecture were taken from Professional gambling. This is an updated version of the article: R.Rodriguez, R. and Vriend, G. (1997) "Professional gambling", in Vergoten, G. and Theophanides, T. (eds.) Proceedings of the NATO Advanced Study Institute on Biomolecular Structure and Dynamics: Recent Experimental and Theoretical Advances.

Protein structure prediction: a practical approach, edited by Michael J.E. Sternberg, contains a collection of articles covering several of the areas mentioned in this lecture.

Principles of Protein Structure, Comparative Protein Modelling and Visualisation has material from an internet course on protein structure and modelling.

ModBase is a database of three-dimensional protein models produced by comparative modelling.

A short discussion of state-of-the-art techniques in protein structure prediction, and their applications, is given in:

Baker, D., and Sali, A. (2001) Protein structure prediction and structural genomics. Science, 294, 93-96. (David Baker's publication list)

A constraint logic programming approach to side-chain placement is described in:

Swain, M.T. and Kemp, G.J.L. (2001) A CLP approach to the protein side-chain placement problem. In Walsh, T. (ed.) Principles and Practice of Constraint Programming - CP2001, Lecture Notes in Computer Science (vol. 2239), Springer-Verlag, Berlin, pp 479-493. (PDF)